2 edition of Investigations on the urinary excretion of adrenal cortical steroids in man. found in the catalog.
Investigations on the urinary excretion of adrenal cortical steroids in man.
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disease but was normal with respect to adrenal cortical function. The male patient had clinical evidence of hypoleydigism, a high excretion of follicle-stimulating hormone in the urine, a high ketosteroid excretion, and, as demonstrated at exploration at the age of 8, bilateral rudimentary testes. Thus, the evidence for lack of testicular. the adrenal cortex was indeed the source of these urinary estrogens or their precursors. This type of investigation does not prove that the normal adrenal cortex has anything to do with sterility in the absence of adrenal disease but it does show that normal adrenal cortical tissue is a potential source of.
The analysis of h excretion profiles of urinary steroids in 18 patients suffering from Cushing's syndrome or adrenocortical tumors revealed typical patterns when compared to 37 healthy control persons, 24 patients with obesity, and 6 patients with hirsutism. The validation of eight criteria — increased excretion of free cortisol, 6β-hydroxycortisol, 20α-dihydrocortisol, 11β. The urinary ketosteroid excretion after corti-cotiophin provides a more valuable indication of adrenal cortical function and many of the current tests rely on this estimation. In males, however, the ketosteroids are only partly derived from the adrenal cortex, andsometimesa clearly defined rise after corticotrophin is not obtained even in.
INCREASES IN ADRENAL CORTICAL FUNCTION ON URINARY ALPHAKETOLIC STEROID METABOLITES F. C. Dohan, , Irmgard Landolt, Walter Applin ' This investigation was supported in part by research grant H from the National Heart Institute, us exposed the urinary steroids to pH 1 . diurnal variation in the urinary excretion of neutral lipid-soluble reducing steroids in congestive cardiac failure and cirrhosis of the liver with ascites 1, 2 Ralph Goldman and Samuel H. Bassett Metabolic Unit, General Medical Research Program, Veterans Administration Center, Los Angeles.
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Excretion rates of noradrenaline, adrenaline, sodium, potassium and creatinine did not differ significantly between Mawson and Melbourne, nor did urine flow rates. During the cold exposure significant increases occurred, to the same extent at Mawson as in Melbourne, in urine flow rate and in all measured urinary constituents except by: 1.
Author(s): Sprechler,Mogens Title(s): Investigations on the urinary excretion of adrenal cortical steroids in man. Country of Publication: Denmark Publisher: Copenhagen, Munksgaard, Description: 1 v. (various pagings) ill. Language: English Other Subject(s): Hormones / Steroid Notes: Five reports, reprinted from Acta endocrinologica.
At the time of evaluation the diagnosis of Cushing's syndrome could not be made in these patients since they had normal values for the following studies; basal urinary ketogenic steroid excretion, adrenal cortical suppression with dexamethasone, and plasma 17 Cited by: Urinary Excretion of Parathyroid Hormone in Man: Effects of Calcium Loads, Protein-Free Diets, Adrenal Cortical Steroids and Neoplastic Disease 1.
LEONARD P. ELIEL. 1 Cancer Section of the Oklahoma Medical Research Institute and the Department of Medicine, " This investigation was supported by USPHS Research Grants C and CA(01 Cited by: Urinary Free Cortisol Excretion. For many years, the diagnosis of Cushing syndrome was based on the measurement of urinary metabolites of cortisol (hour urinary hydroxycorticosteroid or oxogenic steroid excretion, depending on the method used).
However, the sensitivity and specificity of these methods are poor, and most centers have. Click on the article title to read more. Urinary free Cortisol (UFC) excretion was determined in 60 depressed inpatients and in 35 psychiatric inpatients with other disorders.
UFC determination is a simple and informative indicator of adrenal cortical activation and its application to psychoendocrine studies is recommended. A preliminary investigation of steroid excretion in. The present investigation was undertaken to measure gastric secretion in patients with Cushing's syndrome before and after treatment by subtotal adrenalectomy, and to discover whether, in these or in other people, there was any correlation between the level of gastric secretion and the urinary excretion of adrenal cortical steroids.
Measurement of urinary excretion of corticosteroid (any steroid hormone produced by the adrenal cortex) metabolites has been used to evaluate adrenal function for many years. However, measurement of urinary cortisol excretion is more sensitive for the diagnosis of hypercortisolism and has largely supplanted the older assays.
COVID campus closures: see options for getting or retaining Remote Access to subscribed content. Excretion of steroidal substances by the adrenal cortex in various diseases. J Clin Endocrinol Metab. Nov; 11 (11)– GOLDMAN R, BASSETT SH. Diurnal variation in the urinary excretion of neutral lipid-soluble reducing steroids in congestive cardiac failure and cirrhosis of the liver with ascites.
Effects of Eight-Hour Intravenous Infusions of ACTH and the Adrenocortical Steroids in Normal Man. Basal Gastric Secretion, and Plasma and Urinary Pepsinogen 1, 2 B. Hirschowitz, D. Streeten, 3 J. London, and H. Pollard. Urinary steroid excretions were studied in normal postmenopausal women (age limits 55–75 yr) taking part in a prospective study on breast cancer, designed by de Waard in the Netherlands (“Kamper-foelie or Honeysuckle” project).
Out of the women in this study, a small control group was selected, representative of the normal population. Three abnormal patterns of urinary steroid excretion were identified in patients with adrenocortical carcinoma at presentation and/or follow-up of residual disease: (1) hypersecretion in multiple.
Honour has 45 years of experience in analyzing steroids mainly by gas chromatography and mass spectrometry and applying these results to the investigation of patients with endocrine disorders. His work has included the diagnosis of inherited disorders of blood pressure, sex determination, infertility, osteoporosis, and salt balance in the body.
Urinary steroid excretion was increased before resection of the primary tumor. In our patient, ACC metastases did not appear to produce excess amounts of steroids, but this may be related to the relatively small tumor volume at that time. FIG. Section showing a small focus of a lymph node metastasis of ACC.
Tumor. Simultaneous estimation of urinary steroids by semi-automated gas chromatography. Investigation of neo-natal infants and children with abnormal steroid synthesis.
Clin Chim Acta. Jun 1; 69 (2)– Abraham GE, Chakmakjian ZH. Serum steroid levels during the menstrual cycle in a bilaterally adrenalectomized woman. J Clin Endocrinol Metab. THE ROLE of the adrenal cortex in promoting the formation of carbohydrate from protein sources has been demonstrated in experimental animals (1).
Normal Urinary Excretion and the Clinical. URINARY EXCRETION OF ADRENAL CORTICAL STEROIDS URINARY EXCRETION OF ADRENAL CORTICAL STEROIDS Venning, Eleanor H.; Browne, J. It has become apparent in recent years, through the work of many investigators, that the adrenal cortex has a variety of functions.
The substances so far derived from it may be roughly divided into three groups: (1). prednisone on adrenal steroid hormone production was examined using hour urinary steroid hormone profiling.
Five women, who were chronically taking low-dose prednisone, were tested, and the relevant literature was reviewed. As expected, adrenal glucocorticoid production, measured by urinary. Urinary Cortisol excretion determined by competitive protein-binding radioassay: a test of adrenal cortical function.
Journal of Laboratory and Clinical Medic .The adrenal cortex is believed to secrete steroids with androgenic and estrogenic activity or precursors which are transformed to androgenic or estrogenic substances outside the adrenal cortex.
Howard and Migeon () in Chapter 5 of Part 1 of this Volume have reviewed the evidence for the secretion of sex hormones by the normal adrenal cortex.urinary steroid profiling which is a multi component analysis using gas chromatography and mass spectrometry (GC-MS) designed to reveal, at the biochemical level, defects in metabolism largely of adrenal cortical steroids.
The gonadal steroid metabolites are nearly always present at lower levels than the adrenal.